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KMID : 0438219770140010141
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Korea University Medical Journal
1977 Volume.14 No. 1 p.141 ~ p.150
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Influences of Ca and Mg on the changes of blood sugar, plasma nonesterified fatty acid and serum inorganic phosphorus levels induced by tyramine and epinephrine
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Abstract
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Sutherland and his colleagues formulated the concept of cyclic AMP as a second messenger in the actions of epinephrine, and many studies agree with early work showing an inhibition of adenyl cyclase by excess calcium. Titus et al. reported that the neuronal uptake of norepinephrine was enhanced by addition of Ca and Mg.
In this paper, the influences of Ca and Mg on the changes of blood sugar, plasma nonesterified fatty acid and serm inorganic phosphorus levls of rabbits which were induced by tyramine and epinephrine injection were investigated.
The results obtained were summarized as follows;
1. The increase of blood sugar induced by tyramine and epinephrine injection was inhibited by Ca or Mg pretreatment, and especially, the blood sugar level of rabbits pretreated with Ca was decereased below the normal value by tyramine injection.
2. The increase of plasma nonesterified fatty acid induced by tyramine injection was not affected by Ca or Mg pretreatment, but the increase by epinephrine was inhibited by Ca or Mg pretreatment.
3. The transient decrease of serum inorganic phosphorus induced by tyramine injection was prolonged by Ca pretreatment, but inhibited by Mg pretreatment. And the marked decrease of serum inorgainc phosphorus induced by epinephrine injection was not affected by Ca or Mg pretreatment.
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